Mglu3

mglu3

What does mGlu3 stand for?

Metabotropic glutamate receptors type 3 (mGlu3, encoded by GRM3) are increasingly related to cognitive functioning, including the working memory operations of the prefrontal cortex (PFC).

Why is mGlu3 only expressed on astrocytic and microglial processes?

The finding that mGlu3 were predominately expressed on astrocytic and microglial processes rather than in their cell bodies is a challenge, given the relatively low resolution of multiple-label IF, and the small size of these glial processes.

What is the function of mGluR3 in schizophrenia?

Deficits in mGluR3 signaling have been linked to impaired cognition in humans, and to increased risk of schizophrenia, consistent with their expanding role in cortical evolution. In humans, mGluR3 is encoded by the GRM3 gene on chromosome 7.

Is mGluR3 a truncated form of the glutamate receptor?

Expression of a truncated secreted form of the mGluR3 subtype of metabotropic glutamate receptor. Biochemical and Biophysical Research Communications. 319 (2): 622–8. doi: 10.1016/j.bbrc.2004.05.032.

Where is mGlu3 found in the brain?

In rhesus monkeys, mGlu3 are most commonly expressed on glia (36%), but are also very prominent on layer III dendritic spines (23%) in the dorsolateral PFC (dlPFC) where they enhance working memory-related neuronal firing.

What is mGlu3 immunohistochemistry?

For mGlu3 immunohistochemistry, a well-characterized rabbit polyclonal antibody raised against a synthetic peptide corresponding to the N-terminal (extracellular) domain of human mGlu3 and purified by peptide immunogen affinity column was obtained commercially (G1545, Sigma-Aldrich) for use in this study.

What is the function of mGluR2?

The receptor functions as an autoreceptor for glutamate, that upon activation, inhibits the emptying of vesicular contents at the presynaptic terminal of glutamatergic neurons. In humans, mGluR2 is encoded by the GRM2 gene on chromosome 3.

Why is mGlu3 only expressed on astrocytic and microglial processes?

The finding that mGlu3 were predominately expressed on astrocytic and microglial processes rather than in their cell bodies is a challenge, given the relatively low resolution of multiple-label IF, and the small size of these glial processes.

Is mGluR3 a therapeutic target in schizophrenia?

Finally, preclinical findings have made mGluR3 a putative therapeutic target, and now direct evidence for antipsychotic efficacy of a group II mGluR agonist has emerged from a randomised clinical trial in schizophrenia. Together these data implicate mGluR3 in aetiological, pathophysiological and pharmacotherapeutic aspects of the disorder.

Does mGluR3 have a special role in long-term depression?

Differentiation of mGluR3 from mGluR2 has been problematic because of the lack of selective ligands and antibodies; the available data suggest particular roles for mGluR3 in long-term depression, in glial function and in neuroprotection.

Is mGluR3 a glial receptor?

This has been perplexing, as mGluR3 has been considered glial receptors, and mGluR2 and mGluR3 have been thought to have similar functions, reducing glutamate transmission.

What does mGluR3 stand for?

1 Department of Psychiatry, University of Oxford, Neurosciences Building, Warneford Hospital, Oxford, UK. paul.harrison@psych.ox.ac.uk Group II metabotropic glutamate receptors (mGluRs) comprise mGluR2 (mGlu2; encoded by GRM2) and mGluR3 (mGlu3; encoded by GRM3) and modulate glutamate neurotransmission and synaptic plasticity.

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